Naoya Yahagi Selected Research

Sterol Regulatory Element Binding Proteins

6/2014	MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.
1/2013	MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.
12/2012	Elovl6 promotes nonalcoholic steatohepatitis.
12/2003	Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.

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Naoya Yahagi Research Topics

Disease

15	Insulin Resistance 01/2020 - 05/2002
14	Obesity 01/2019 - 05/2002
10	Atherosclerosis 07/2018 - 08/2002
7	Type 2 Diabetes Mellitus (MODY) 01/2021 - 02/2005
7	Inflammation (Inflammations) 03/2020 - 12/2012
4	Hypertriglyceridemia 01/2016 - 12/2003
4	Neoplasms (Cancer) 01/2013 - 07/2003
3	Non-alcoholic Fatty Liver Disease 01/2020 - 01/2016
3	Body Weight (Weight, Body) 01/2019 - 12/2014
3	Fatty Liver 12/2015 - 12/2003
3	Hyperglycemia 01/2009 - 12/2003
2	Fibrosis (Cirrhosis) 01/2018 - 12/2012
2	Metabolic Diseases (Metabolic Disease) 11/2017 - 04/2012
2	Hyperlipidemias (Hyperlipidemia) 07/2017 - 01/2016
2	Hypercholesterolemia 11/2016 - 09/2006
2	Hypoglycemia (Reactive Hypoglycemia) 01/2016 - 12/2003
2	Hypertrophy 07/2014 - 07/2008
1	Muscle Weakness 01/2022
1	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022
1	Cognitive Dysfunction 01/2021
1	Wounds and Injuries (Trauma) 06/2020
1	Osteoarthritis 03/2020
1	Knee Osteoarthritis 03/2020
1	Synovitis 03/2020
1	Hyperuricemia 01/2020
1	Dyslipidemias (Dyslipidemia) 07/2018
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2018
1	Albuminuria 07/2018
1	Lipodystrophy 01/2018
1	Weight Loss (Weight Reduction) 11/2017
1	Alcoholic Fatty Liver 01/2016
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2016
1	Gallstones (Gallstone) 12/2015
1	Necrosis 10/2015
1	Muscular Diseases (Myopathy) 10/2015
1	Rhabdomyolysis 10/2015
1	Myotoxicity 10/2015
1	Coronary Stenosis (Coronary Artery Stenosis) 01/2015
1	Hyperlipoproteinemia Type I (Lipoprotein Lipase Deficiency, Familial) 01/2013

Drug/Important Bio-Agent (IBA)

9	CholesterolIBA 01/2019 - 08/2002
8	Fatty Acids (Saturated Fatty Acids)IBA 07/2017 - 12/2003
7	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 04/2012
6	LipidsIBA 01/2019 - 11/2008
6	Sterol Regulatory Element Binding Protein 1IBA 01/2018 - 06/2005
5	EnzymesIBA 01/2016 - 05/2002
5	Triglycerides (Triacylglycerol)IBA 01/2013 - 12/2003
4	Fatty Acid ElongasesIBA 01/2020 - 10/2007
4	Insulin (Novolin)FDA Link 01/2020 - 04/2004
4	oxidized low density lipoproteinIBA 07/2018 - 09/2006
4	Transcription Factors (Transcription Factor)IBA 01/2018 - 07/2003
4	LeptinIBA 11/2017 - 05/2002
4	Sterol Regulatory Element Binding ProteinsIBA 06/2014 - 12/2003
4	Sterol Esterase (Hormone-Sensitive Lipase)IBA 01/2011 - 08/2002
4	Cholesterol Esters (Cholesteryl Esters)IBA 01/2011 - 08/2002
4	Messenger RNA (mRNA)IBA 11/2007 - 05/2002
3	SterolsIBA 08/2011 - 05/2002
3	ElementsIBA 08/2011 - 05/2002
2	Sucrose (Saccharose)IBA 01/2020 - 07/2014
2	Malondialdehyde (Propanedial)IBA 07/2018 - 01/2015
2	PalmitatesIBA 01/2017 - 12/2012
2	Oleic Acid (Oleate)IBA 01/2017 - 12/2015
2	Monounsaturated Fatty AcidsIBA 07/2014 - 09/2011
2	GlycogenIBA 04/2012 - 04/2004
2	LDL Receptors (LDL Receptor)IBA 09/2011 - 08/2011
2	Lipoproteins (Lipoprotein)IBA 08/2011 - 07/2004
2	Insulin Receptor Substrate ProteinsIBA 10/2007 - 04/2004
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 03/2020
1	Phospholipases (Phospholipase)IBA 01/2020
1	Uric Acid (Urate)IBA 01/2020
1	CeramidesIBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	policosanolIBA 01/2019
1	1-octacosanol (octacosanol)IBA 01/2019
1	LDL CholesterolIBA 07/2018
1	PhosphoenolpyruvateIBA 01/2018
1	Genetic Markers (Genetic Marker)IBA 01/2018
1	Sodium-Glucose Transporter 2 InhibitorsIBA 11/2017
1	Sodium-Glucose Transport ProteinsIBA 11/2017
1	Biological ProductsIBA 11/2017
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 07/2017
1	Methionine (L-Methionine)FDA Link 01/2016
1	Co-Repressor ProteinsIBA 01/2016
1	Transaminases (Aminotransferases)IBA 01/2016
1	Docosahexaenoic AcidsIBA 01/2016
1	Eicosapentaenoic AcidIBA 01/2016
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2016
1	Choline (Choline Chloride)IBA 01/2016
1	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 10/2015
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2015
1	Creatine Kinase (Creatine Phosphokinase)IBA 10/2015
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2013
1	Apolipoprotein C-II (ApoC2)IBA 01/2013
1	Apolipoproteins C (ApoC)IBA 01/2013
1	InflammasomesIBA 12/2012
1	Basic Helix-Loop-Helix Transcription FactorsIBA 04/2012

Therapy/Procedure

1	Cardiopulmonary Resuscitation (CPR) 01/2022
1	Cryotherapy (Therapy, Cold) 06/2020
1	Meniscectomy 03/2020
1	Oral Administration 10/2015